CFS/ME

CFS/ME was until recently a ill defined condition, whose main symptom was fatigue
Other associated conditions were poor sleep, depression and brain fog.
Recently it has been found that the major precipitating factor was functional vitamin B12 deficiency.
In CFS/ME the B12 deficiency appears to be related to functional B2 deficiency
Treatment of CFS must address the primary cause of vitamin B12 deficiency.
Treatment must establish whether the vitamin B12 deficiency is absolute or paradoxical deficiency
If the cause is paradoxical B12 deficiency, then treatment must address this
Treatment involves fixing functional vitamin B2 deficiency first
Once functional B2 deficiency has been resolved then the functional B12 deficiency can be addressed.

Chronic Fatigue Syndrome (CFS) or Myalgic Encephalomyelitis (ME)

Chronic Fatigue Syndrome (CFS) or Myalgic Encephalomyalitis (ME) is an ill defined disease that is characterized by a post exercise tiredness or malaise. The condition usually lasts for more than six months and in affected individuals is very disabling. Symptoms include muscle soreness, inability to concentrate (brain fog), headaches and severe mental and physical fatigue. In addition these symptoms may be accompanied by sensitivity to light, sounds and smells, digestive disturbances, depression, painful and often slightly swollen lymph nodes, and it may also be accompanied by cardiac and respiratory problems.

Research CFS/ME

We have compared the metabolic analysis of those with CFS/ME to healthy controls using the Organic Acids Test of urine, and a Hair Metals Test Analysis. This has enabled to identify mineral and nutritional deficiencies in CFS/ME and have found that Iodine/Selenium and/or Molybdenum deficiency is very common, and have developed a protocol to treat the deficiencies and then fix the functional B2 and B12 deficiency, so enable resolution of the condition.

We have summarized the finding in the Research section, and have been able to identify the Cause of the condition as well as a Treatment strategy. In addition, we have expanded on the concept of Paradoxical B12 deficiency. The treatment strategy involves re-establishing active riboflavin sufficiency and functional vitamin B12 sufficiency, which when combined with parenteral administration of mixed Adenosyl/Methyl B12. Hence the protocol as been named the RnB protocol.

The RnB protocol has been found to be highly effective in reversing the symptoms of CFS (RnB protocol)

Creatine supplementation has also proven to have some success in some individuals (Allen, 2012).

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Russell-Jones, GJ 2022 Functional vitamin B12 deficiency in CFS. Int J. Psychiatry 27 Jul 2022 PDF

Russell-Jones, GJ 2022 Paradoxical vitamin B12 deficiency PDF